HCID 54388349, compound → HCID 19004355, compound

HRID 2225654Notes

Reaction equation

HRID 2225654 reaction equation
C[O:2][C:3](=[O:25])[C:4](=[O:24])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[N+:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:9]=[CH:10][C:5]([C:4](=[O:24])[C:3]([OH:25])=[O:2])=[CH:6][CH:7]=2)=[CH:20][CH:19]=1)([O-:23])=[O:22]

Participants

4

Reactant 1

HCID 54388349HCID 54388349, compound

Product 1

HCID 19004355HCID 19004355, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(4-nitrophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (4:1) molar hydrate (0.65 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided 0.6 g of crude product which solidified and was crystallized from dichloromethane-hexane to give 0.55 g of colorless 4-[[2-(4nitrophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 129°-130° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided 0.6 g of crude product which
  4. customwas crystallized from dichloromethane-hexane

Sources & evidence

ORD record
ord-795ea72127d54a0ca9d2ddfe6d9ca43c
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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