反应详情

A mixture of 4-[[2-(3,4-dimethoxyphenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol and 0.5N sodium hydroxide (8 mL) was heated on the steam bath for 0.5 hours and cooled. 2N hydrochloric acid (5 mL) was added and the resulting solids were filtered and washed with water. The solids were dried by boiling in benzene (20 mL), filtered, hexane (5 mL) was added, and the resulting mixture was chilled to give 0.63 g of colorless 4-[[2-(3,4-dimethoxyphenoxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 140°-141° C.

1. temperaturewas heated on the steam bath for 0.5 hours
2. temperaturecooled
3. filtrationthe resulting solids were filtered
4. washwashed with water
5. customThe solids were dried
6. filtrationfiltered
7. additionhexane (5 mL) was added
8. temperaturethe resulting mixture was chilled