HCID 53839912, compound → HCID 19004410, compound

HRID 2225672Notes

Reaction equation

HRID 2225672 reaction equation
C[O:2][C:3](=[O:23])[C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:22]=[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:7][CH:6]=1)[C:3]([OH:23])=[O:2]

Participants

4

Reactant 1

HCID 53839912HCID 53839912, compound

Product 1

HCID 19004410HCID 19004410, compoundYield 56.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of alpha-oxo-4-[[(3-phenoxy)propyl]oxy]benzeneacetic acid methyl ester (0.63 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction with dichloromethane provided material which was crystallized from diethyl ether-hexane to give 0.34 g of colorless alpha-oxo-4-[[(3-phenoxy)propyl]oxy]benzeneacetic acid, mp 50°-52° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction with dichloromethane provided material which
  3. customwas crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-a613818d8e2041e78498f21d7ce81c9d
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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