HCID 53757285, compound → HCID 19004288, compound

HRID 2225677Notes

Reaction equation

HRID 2225677 reaction equation
C[O:2][C:3](=[O:26])[C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:25]=[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:7][CH:6]=1)[C:3]([OH:26])=[O:2]

Participants

4

Reactant 1

HCID 53757285HCID 53757285, compound

Product 1

HCID 19004288HCID 19004288, compoundYield 69.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of alpha-oxo-4-[[(6-phenoxy)hexyl]oxy]benzeneacetic acid methyl ester (0.75 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.5 g of colorless alpha-oxo-4-[[(6-phenoxy)hexyl]oxy]benzeneacetic acid, mp 121°-122° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-bcf0c61b949f479d8949491a8662ae94
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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