HCID 53815443, compound → HCID 19004380, compound

HRID 2225682Notes

Reaction equation

HRID 2225682 reaction equation
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:21]=[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:6]=1)[C:3]([OH:22])=[O:2]

Participants

4

Reactant 1

HCID 53815443HCID 53815443, compound

Product 1

HCID 19004380HCID 19004380, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of alpha-oxo-4-[[2-(phenylthio)ethyl]oxy]benzeneacetic acid methyl ester (0.5 g) in methanol and 0.5N sodium hydroxide (6 mL) was treated as in Example 19. Extraction provided material which was crystallized from benzene-hexane to give 0.43 g of colorless alpha-oxo-4-[[2-(phenylthio)ethyl]oxy]benzeneacetic acid, mp 72°-73° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided material which
  4. customwas crystallized from benzene-hexane

Sources & evidence

ORD record
ord-b44306ca21cb46fcbcbc94291813db52
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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