反应详情

A solution of 4-[(2-quinolinyl)methoxy]-alpha-oxobenzeneacetic acid methyl ester (0.34 g) in methanol (2 mL) and tetrahydrofuran (8 mL) was treated with 1N sodium hydroxide (1.1 mL) and a white precipitate formed. After 5 minutes, the reaction mixture was concentrated and the residue was acidified with excess hydrochloric acid. The residue was triturated with water (25 mL) and dichloromethane-tetrahydrofuran (150 mL, 9:1) and the solids were crystallized twice from dimethylsulfoxide-acetonitrile-water to give 0.142 g of 4-[(2-quinolinyl)methoxy]-alpha-oxo-benzeneacetic acid, mp 225°-228° C.

1. customa white precipitate formed
2. concentrationthe reaction mixture was concentrated
3. customThe residue was triturated with water (25 mL) and dichloromethane-tetrahydrofuran (150 mL, 9:1)
4. customthe solids were crystallized twice from dimethylsulfoxide-acetonitrile-water