反应详情

温度

155 °C

A mixture of 2-[2-(4-bromo-3,5-dichlorophenoxy)ethoxy]naphthalene (3.28 g) in dimethylformamide (10 mL) and cuprous cyanide (0.833 g) was heated under argon at 155° C. for four hours. The cooled mixture was diluted with aqueous 10% sodium cyanide solution (100 mL) and extracted twice with dichloromethane. The organic solutions were washed in turn with aqueous 10% sodium cyanide solution and water, dried (Na2SO4), filtered and evaporated to give 2.2 g of crude 2,6-dichloro-4-[2-(2-naphthalenyloxy)ethoxy]benzonitrile. A portion crystallized from dichloromethanediethyl ether provide pure colorless material, mp 156°-158° C.

1. extractionextracted twice with dichloromethane
2. washThe organic solutions were washed in turn with aqueous 10% sodium cyanide solution and water
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customevaporated