反应详情

To a hot solution of 4-[2-(1-naphthalenyl)-2-oxoethoxy]-alpha-oxobenzeneacetic acid methyl ester (0.128 g) in methanol (3 mL) and tetrahydrofuran (0.5 mL) was added 1N sodium hydroxide (0.8 mL) followed by water (15 mL). The solvents were removed under reduced pressure, then the solution was acidified with 1N hydrochloric acid (1 mL) and extracted with dichloromethane (1×20 mL, 1×10 mL). The combined organic layers were washed with water, dried (MgSO4) and evaporated and the resulting yellow solid (0.107 g) was crystallized from ethyl acetate-hexane to provide 0.063 g of 4-[2-(1-naphthalenyl)-2-oxoethoxy]-alpha-oxobenzeneacetic acid, mp 141°-143° C.

1. customThe solvents were removed under reduced pressure
2. extractionextracted with dichloromethane (1×20 mL, 1×10 mL)
3. washThe combined organic layers were washed with water
4. dry with materialdried (MgSO4)
5. customevaporated
6. customthe resulting yellow solid (0.107 g) was crystallized from ethyl acetate-hexane