Sodium Hydroxide → HCID 86748118, compound

HRID 2225859Notes

Reaction equation

C([O:3][C:4](=[O:29])/[C:5](=[N:25]/[O:26][CH2:27][CH3:28])/[C:6]1[S:7][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[CH:9][CH:10]=1)C.[OH-].[Na+]>CO.O1CCCC1>[CH2:27]([O:26]/[N:25]=[C:5](\[C:6]1[S:7][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[CH:9][CH:10]=1)/[C:4]([OH:29])=[O:3])[CH3:28]

Participants

Conditions

Temperature: 55 °C

Procedure

As in Example 306, a solution of (Z)-alpha-(ethoxyimino)-5-[2-(2-naphthalenyloxy) ethoxy]-2-thiopheneacetic acid ethyl ester (0. 141 g) in methanol (2 mL) and tetrahydrofuran (1 mL) was treated with 4N sodium hydroxide (0.5 mL) and the stirred mixture was heated at 55° C. for 30 minutes. After the normal work up, the product was crystallized from ethyl acetate-hexane to furnish 0.07 g of (Z-alpha-(ethoxyimino)-5-[2-(2-naphthalenyloxy)ethoxy]-2-thiopheneacetic acid, mp 114° C. (dec.).

Workup

customAfter the normal work up, the product was crystallized from ethyl acetate-hexane

Sources & evidence

ORD record: ord-99290c6d2e7040c1ad47e8d63fab25e0
Source dataset: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05344843

Reaction notes

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