Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate → 4-[2-Fluoro-4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 222589Notes

Reaction equation

HRID 222589 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15]S(C)(=O)=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:20][C:21]1[CH:26]=[C:25]([C:27]2[CH2:28][CH2:29][N:30]([S:33]([CH3:36])(=[O:35])=[O:34])[CH2:31][CH:32]=2)[CH:24]=[CH:23][C:22]=1O>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][C:22]2[CH:23]=[CH:24][C:25]([C:27]3[CH2:32][CH2:31][N:30]([S:33]([CH3:36])(=[O:35])=[O:34])[CH2:29][CH:28]=3)=[CH:26][C:21]=2[F:20])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 2765838Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylateHCID 668652462-Fluoro-4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenol

Product 1

HCID 668644984-[2-Fluoro-4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Procedure

Prepared essentially as Preparation 2 (step 2) using 4-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester and 2-fluoro-4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenol as starting materials. MS (m/z) 414 (M−55).

Workup

  1. customPrepared essentially as Preparation 2 (step 2)

Sources & evidence

ORD record
ord-565b5ea5dd5d4963898d7ea3dcfd14a8
Source dataset
uspto-grants-2012_06
Patent number
US08207344B2

Reaction notes

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