2-Fluoro-2-methylpropanoic acid → 4-{3-Fluoro-4-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-ylmethoxy]-phenyl}-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine

HRID 222590Notes

Reaction equation

HRID 222590 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([C:17]2[CH2:18][CH2:19][N:20]([S:23]([CH3:26])(=[O:25])=[O:24])[CH2:21][CH:22]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[F:27][C:28]([CH3:33])([CH3:32])[C:29](O)=O>>[F:2][C:3]1[CH:4]=[C:5]([C:17]2[CH2:22][CH2:21][N:20]([S:23]([CH3:26])(=[O:25])=[O:24])[CH2:19][CH:18]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH:11]1[CH2:12][CH2:13][N:14]([CH2:29][C:28]([F:27])([CH3:33])[CH3:32])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 27828282-Fluoro-2-methylpropanoic acidHCID 668653114-[3-Fluoro-4-(piperidin-4-ylmethoxy)-phenyl]-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine hydrochloride salt

Product 1

HCID 581111564-{3-Fluoro-4-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-ylmethoxy]-phenyl}-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine

Procedure

Prepared essentially as Example 2 starting from 4-[3-fluoro-4-(piperidin-4-ylmethoxy)-phenyl]-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine hydrochloride salt and 2-fluoro-2-methyl-propionic acid. MS (m/z) 443 (M+1).

Sources & evidence

ORD record
ord-1ebfbef68fdb4fc3bc605b081352aec8
Source dataset
uspto-grants-2012_06
Patent number
US08207344B2

Reaction notes

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