HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-2-methylpropanoic acid → 4-{3-Fluoro-4-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-ylmethoxy]-phenyl}-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-2-methylpropanoic acid | HCID 2782828 | — |
| Reactant | 4-[3-Fluoro-4-(piperidin-4-ylmethoxy)-phenyl]-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine hydrochloride salt | HCID 66865311 | — |
| Product | 4-{3-Fluoro-4-[1-(2-fluoro-2-methyl-propyl)-piperidin-4-ylmethoxy]-phenyl}-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine | HCID 58111156 | — |
Reaction Steps
Prepared essentially as Example 2 starting from 4-[3-fluoro-4-(piperidin-4-ylmethoxy)-phenyl]-1-methanesulfonyl-1,2,3,6-tetrahydro-pyridine hydrochloride salt and 2-fluoro-2-methyl-propionic acid. MS (m/z) 443 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207344B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-1ebfbef68fdb4fc3bc605b081352aec8 |
| Source note | uspto-grants-2012_06 |