Hydrochloric Acid → HCID 19005066, compound

HRID 2225908Notes

Reaction equation

HRID 2225908 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([CH2:12][F:13])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CCOCC>[NH2:1][CH:2]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:10](=[O:11])[CH2:12][F:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131717226HCID 131717226, compound

Product 1

HCID 19005066HCID 19005066, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of Boc-PheCH2F (0.75 g, 2.67 mmol) in anhydrous ether (5 mL) was added a saturated solution of HCl in ether (30 mL). The mixture was stirred vigorously at room temperature for 45 minutes. The suspension was filtered, washed with ether (10 mL), and pumped dry, to give a white solid (0.31 g, 54%). This material was immediately used in the next step.

Workup

  1. filtrationThe suspension was filtered
  2. washwashed with ether (10 mL)
  3. custompumped dry

Sources & evidence

ORD record
ord-b7a6f4e011d14082bf3fc0a6f9aa0f49
Source dataset
uspto-grants-1994_09
Patent number
US05344939

Reaction notes

Loading…