Gamma-Butyrolactone → 6-hydroxy-1-phenylhexane-1,3-dione

HRID 2225983Notes

Reaction equation

HRID 2225983 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[C:10]1(=[O:15])[O:14][CH2:13][CH2:12][CH2:11]1.C[O-].[Na+]>>[OH:15][CH2:10][CH2:11][CH2:12][C:13](=[O:14])[CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]

Participants

4

Reactant 3

HCID 7302Gamma-ButyrolactoneHCID 7410AcetophenoneHCID 10942334Sodium Methoxide

Product 1

HCID 27633446-hydroxy-1-phenylhexane-1,3-dione

Procedure

60.0 g of acetophenone, 47.4 g of butyrolactone and 99.0 g of sodium methylate (30% solution in methanol) are reacted in the same manner as described in Example 8. After working up as described in Example 8, the product precipitates from the mother solution after several hours. The precipitate is isolated by filtration, washed with water and dried to constant weight under vacuum at ca. 30° C.

Workup

  1. customthe product precipitates from the mother solution after several hours
  2. customThe precipitate is isolated by filtration
  3. washwashed with water
  4. customdried to constant weight under vacuum at ca. 30° C.

Sources & evidence

ORD record
ord-95843510d2824a318f31f788f6c5a7c1
Source dataset
uspto-grants-1994_09
Patent number
US05344992

Reaction notes

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