Methyl trifluoroacetate → HCID 178454049, compound

HRID 222600Notes

Reaction equation

HRID 222600 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4][CH2:3]1.[F:16][C:17]([F:23])([F:22])[C:18](OC)=[O:19]>CO>[F:16][C:17]([F:23])([F:22])[C:18]([NH:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4][CH2:3]1)=[O:19]

Participants

4

Reactant 2

HCID 9893Methyl trifluoroacetateHCID 178418966HCID 178418966, compound

Product 1

HCID 178454049HCID 178454049, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A solution of tert-butyl cis-4-aminocyclohexanecarbamate (22.1 g, 103 mmol) and methyl trifluoroacetate (11 ml, 110 mmol) in 110 ml of methanol is stirred at RT for 4 h. After the reaction mixture has been cooled down to 0° C., the precipitate is filtered off, washed with diethyl ether and dried. Yield: 17.6 g.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-cd24967c90144d7daa7497fca1e6ca06
Source dataset
uspto-grants-2012_06
Patent number
US08207349B2

Reaction notes

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