HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → (S)-4-(N,N-Di-n-pentylcarbamoyl)-1-(N,N-diphenylcarbamoyl)-2-(2-(4-morpholinyl)ethylaminocarbonyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | 1-(N,N-diphenylcarbamoyl)-4-(N,N-di-n-pentylcarbamoyl)piperazine-2-carboxylic acid | HCID 9870914 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | (S)-4-(N,N-Di-n-pentylcarbamoyl)-1-(N,N-diphenylcarbamoyl)-2-(2-(4-morpholinyl)ethylaminocarbonyl)piperazine | HCID 54538407 | 46.5% |
Reaction Steps
According to the procedure of Example 1, Step E above, 47 mg (0.09 mmole) of 1-(N,N-diphenylcarbamoyl)-4-(N,N-di-n-pentylcarbamoyl)piperazine-2-carboxylic acid, 3 mg (0.02 mmole) of DMAP, 25 mg (0.13 mmole) of EDAC, and 24 mg (0.18 mmole) of 4-(2-aminoethyl)morpholine after purification by flash chromatography on 16 g of silica gel with 100:3CH2Cl2 :MeOH provided 26 mg (46%) of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344830 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-e1da493f1b254e4b9214105d3abcc999 |
| Source note | uspto-grants-1994_09 |