HRID2226026

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

HCID408285

2-Morpholinoethylamine

C6H14N2O

结构：CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1

HCID9870914

未命名化合物

PRODUCTS

生成物

结构：CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN2CCOCC2)C1

HCID54538407

未命名化合物

收率 46.5%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

According to the procedure of Example 1, Step E above, 47 mg (0.09 mmole) of 1-(N,N-diphenylcarbamoyl)-4-(N,N-di-n-pentylcarbamoyl)piperazine-2-carboxylic acid, 3 mg (0.02 mmole) of DMAP, 25 mg (0.13 mmole) of EDAC, and 24 mg (0.18 mmole) of 4-(2-aminoethyl)morpholine after purification by flash chromatography on 16 g of silica gel with 100:3CH2Cl2 :MeOH provided 26 mg (46%) of an oil.

WORKUP

后处理

customafter purification by flash chromatography on 16 g of silica gel with 100:3CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1da493f1b254e4b9214105d3abcc999
来源数据集: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05344830
来源说明: uspto-grants-1994_09

反应 SMILES

[C:1]1([N:7]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16](=[O:28])[N:17]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:12][CH:11]2[C:29](O)=[O:30])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN=C=NCCCN(C)C.[NH2:49][CH2:50][CH2:51][N:52]1[CH2:57][CH2:56][O:55][CH2:54][CH2:53]1>CN(C1C=CN=CC=1)C>[CH2:23]([N:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[C:16]([N:13]1[CH2:14][CH2:15][N:10]([C:8](=[O:9])[N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[C@H:11]([C:29]([NH:49][CH2:50][CH2:51][N:52]2[CH2:57][CH2:56][O:55][CH2:54][CH2:53]2)=[O:30])[CH2:12]1)=[O:28])[CH2:24][CH2:25][CH2:26][CH3:27]