Formaldehyde → 2-(pyrazin-2-yl)ethanol

HRID 2226044Notes

Reaction equation

HRID 2226044 reaction equation
[CH3:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[CH2:8]=[O:9]>>[OH:9][CH2:8][CH2:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 79762-Methylpyrazine

Product 1

HCID 5222472-(pyrazin-2-yl)ethanolYield 32%

Procedure

A mixture of 90.0 g (956 mmol) of 2-methylpyrazine and 6.4 g (212 mmol) of paraformaldehyde was heated in a stainless steel autoclave at 165° C. for 5 hours, The residue was distilled under iced aspirator pressure (ca. 10 mmHg) to yield 8.28 g (32%) of a light pink oil.

Workup

  1. distillationThe residue was distilled under iced aspirator pressure (ca. 10 mmHg)

Sources & evidence

ORD record
ord-9ae351cf1bac4f44b92cbc37972c8a16
Source dataset
uspto-grants-1994_09
Patent number
US05344830

Reaction notes

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