Hydroxyamine hydrochloride → HCID 85617427, compound

HRID 2226152Notes

Reaction equation

HRID 2226152 reaction equation
[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[CH2:2]2.[ClH:9].[NH2:10][OH:11]>CO>[ClH:9].[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=[N:10][OH:11])[CH2:2]2

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 108554071-Azabicyclo[2.2.1]heptan-3-one

Product 1

HCID 85617427HCID 85617427, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Azabicyclo[2.2.1]heptan-3-one (2 g, 18 mmol) and hydroxylamine hydrochloride (1.25 g, 18 mmol) were dissolved in 10 mL MeOH and stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo. The crystalline residue was recrystallized from ethanol to afford 2.04 g (70%) of the title product, mp 211° C.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crystalline residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-50be6217ad3e4c348176646c53ef86e3
Source dataset
uspto-grants-1994_09
Patent number
US05346911

Reaction notes

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