Trifluoroacetic acid → HCID 58100971, compound

HRID 222627Notes

Reaction equation

HRID 222627 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[C:17]3[CH:34]=[CH:35][CH:36]=[CH:37][C:16]=3[N:8]2[C:9](=[O:15])[C:10]=1[O:11][C:12](=[O:14])[CH3:13])=[O:4].FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[C:17]3[CH:34]=[CH:35][CH:36]=[CH:37][C:16]=3[N:8]2[C:9](=[O:15])[C:10]=1[O:11][C:12](=[O:14])[CH3:13])=[O:4]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58101071HCID 58101071, compound

Product 1

HCID 58100971HCID 58100971, compound

Procedure

3-Acetoxy-10-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-ethyl]-4-oxo-4,10-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine-2-carboxylic acid methyl ester (33 mg, 0.064 mmol) was treated with trifluoroacetic acid (0.20 mL) and stirred for one hour at room temperature. After this time, the mixture was concentrated and the crude residue was the desired product (27 mg, 100%).

Workup

  1. concentrationAfter this time, the mixture was concentrated

Sources & evidence

ORD record
ord-2a50a168133e496fa9a01369f1fb17ec
Source dataset
uspto-grants-2012_06
Patent number
US08207334B2

Reaction notes

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