反应详情

2-Fluorobenzonitrile (605 mg, 5 mmol) and 85% aqueous hydrazine hydrate (352 mg, 6 mmol) were mixed with 1-butanol (3 mL). The mixture was heated at reflux with stirring for 5 h then cooled to room temperature. The resulting precipitate was collected by filtration and washed with dichloromethane and the filter cake was dried in vacuo to give 3-amino benzpyrazole (293 mg, 44%).

1. temperatureThe mixture was heated
2. temperatureat reflux
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with dichloromethane
5. customthe filter cake was dried in vacuo