Ammonium formate → HCID 23362662, compound

HRID 2226373Notes

Reaction equation

HRID 2226373 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][O:7][CH2:6][CH:5]([CH2:9][NH2:10])[N:4]1CC1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:1][CH2:2][CH:3]1[CH2:8][O:7][CH2:6][CH:5]([CH2:9][NH2:10])[NH:4]1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 23362648HCID 23362648, compound

Product 1

HCID 23362662HCID 23362662, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

3,5-Bis--aminomethyl--4-benzylmorpholine (1.3 g, 5.5 mmol) was dissolved in methanol (50 ml) . Ammoniumformiate (1.4 g, 22 mmol) and palladium on activated carbon (10 % , 5 g) were added. The reaction mixture was stirred at 50 ° C. under nitrogen for 3 hours. The catalyst was then filtered off and washed with several small portions of methanol and the solution evaporated to dryness. The tri-amine was used direcly in the next reaction step. FAB/MS: 146 (M+1).

Workup

  1. filtrationThe catalyst was then filtered off
  2. washwashed with several small portions of methanol
  3. customthe solution evaporated to dryness
  4. customThe tri-amine was used direcly in the next reaction step

Sources & evidence

ORD record
ord-4a85a32e6d7742bc8dc128cd61ab1c78
Source dataset
uspto-grants-1994_09
Patent number
US05348954

Reaction notes

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