Sodium cyanoborohydride → HCID 67852613, compound

HRID 2226391Notes

Reaction equation

HRID 2226391 reaction equation
[NH2:1][C@H:2]([C:4]([N:6]1[CH:14]2[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C@H:7]1[C:15]([OH:17])=[O:16])=[O:5])[CH3:3].[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([CH2:27][CH2:28][C:29](=O)[C:30]([OH:32])=[O:31])=[CH:19]1.C([BH3-])#N.[Na+]>>[C:30]([CH:29]([NH:1][C@H:2]([C:4]([N:6]1[CH:14]2[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C@H:7]1[C:15]([OH:17])=[O:16])=[O:5])[CH3:3])[CH2:28][CH2:27][C:20]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[NH:18][CH:19]=1)([OH:32])=[O:31]

Participants

4

Reactant 3

HCID 5003444Sodium cyanoborohydrideHCID 13146116HCID 13146116, compoundHCID 18964897HCID 18964897, compound

Product 1

HCID 67852613HCID 67852613, compound

Procedure

Condense 1-[(S)-alanyl]octahydroindole-2(S)-carboxylic acid (preparable as described in Example 1) and 4-(3-indolyl)-2-oxobutyric acid with sodium cyanoborohydride, using the procedure described in Example 5 to yield the title compound.

Sources & evidence

ORD record
ord-f753f3a9920448f9b08dfd6d3fc12219
Source dataset
uspto-grants-1994_09
Patent number
US05348944

Reaction notes

Loading…