Sodium cyanoborohydride → HCID 67852550, compound

HRID 2226396Notes

Reaction equation

HRID 2226396 reaction equation
[NH2:1][C@H:2]([C:4]([N:6]1[CH:14]2[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C@H:7]1[C:15]([OH:17])=[O:16])=[O:5])[CH3:3].[CH:18]1([CH2:24][C:25](=O)[C:26]([OH:28])=[O:27])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.C([BH3-])#N.[Na+]>>[C:26]([CH:25]([NH:1][C@H:2]([C:4]([N:6]1[CH:14]2[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C@H:7]1[C:15]([OH:17])=[O:16])=[O:5])[CH3:3])[CH2:24][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:28])=[O:27]

Participants

4

Reactant 3

HCID 5003444Sodium cyanoborohydrideHCID 11953639HCID 11953639, compoundHCID 13146116HCID 13146116, compound

Product 1

HCID 67852550HCID 67852550, compound

Procedure

Condense 1-[(S)-alanyl]octahydroindole-2(S)-carboxylic acid (prepared as described in Example 1) and 3-cyclohexyl-2-oxopropionic acid with sodium cyanoborohydride as described in Example 5 to obtain the title compound,

Sources & evidence

ORD record
ord-25ecc08987e5446f86c51ea695aad512
Source dataset
uspto-grants-1994_09
Patent number
US05348944

Reaction notes

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