Ammonium Acetate → 1-[4-(1,1-Dimethylethyl)-2-methyl-5-oxazolyl]-2,2-dimethyl-1-propanone

HRID 2226430Notes

Reaction equation

HRID 2226430 reaction equation
[C:1]([O:4][CH:5]([C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[C:6](=O)[C:7]([CH3:10])([CH3:9])[CH3:8])(=O)[CH3:2].C([O-])(=O)C.[NH4+:22]>C(O)(=O)C.O.[OH-].[Na+]>[CH3:8][C:7]([C:6]1[N:22]=[C:1]([CH3:2])[O:4][C:5]=1[C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:10])[CH3:9]

Participants

6

Reactant 2

HCID 517165Ammonium AcetateHCID 104669154-(Acetyloxy)-2,2,6,6-tetramethyl 3,5-heptanedione

Product 1

HCID 189253781-[4-(1,1-Dimethylethyl)-2-methyl-5-oxazolyl]-2,2-dimethyl-1-propanoneYield 92.5%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 4-(acetyloxy)-2,2,6,6-tetramethyl 3,5-heptanedione (22 g, 0.09 mol) in acetic acid (100 mL) is treated with ammonium acetate (44 g). The reaction mixture is heated at reflux overnight. The reaction mixture is diluted with water and neutralized (to pH 5) by the addition of aqueous sodium hydroxide. The product is extracted into ethyl acetate (3×150 mL) and the combined organic layers are washed with 0.1N NaOH, water, and then brine. The organic layer is dried and evaporated. The residue is taken up in hexane (50 mL) and applied to a pad of silica gel (500 g). The silica pad is eluted with hexane (100 mL). Then the product is eluted from the silica with hexane/ethyl acetate (4:1) to give 18.6 g (91%) of 1-[4-(1,1-dimethylethyl)-2-methyl-5-oxazolyl]-2,2-dimethyl-1-propanone as an oil.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. extractionThe product is extracted into ethyl acetate (3×150 mL)
  4. washthe combined organic layers are washed with 0.1N NaOH, water
  5. customThe organic layer is dried
  6. customevaporated
  7. washThe silica pad is eluted with hexane (100 mL)
  8. washThen the product is eluted from the silica with hexane/ethyl acetate (4:1)

Sources & evidence

ORD record
ord-865500d193a34d9fb3df99c32a17341d
Source dataset
uspto-grants-1994_09
Patent number
US05348957

Reaction notes

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