Morpholine → 4-(6-Chloropyridine-3-carbonyl)morpholine

HRID 222651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 222651
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][N:9]=1>ClCCl>[Cl:7][C:8]1[N:9]=[CH:10][C:11]([C:12]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[O:13])=[CH:15][CH:16]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 27821656-Chloronicotinoyl Chloride

Produkt 1

HCID 8574994-(6-Chloropyridine-3-carbonyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Morpholine (0.2 ml, 2.2 mmol) was added to stirred solution of 6-chloronicotinoyl chloride (250 mg, 1.4 mmol) in dichloromethane (10 ml). After 2 hours the reaction was allowed to cool and the crude mixture was applied to a SCX ion exchange cartridge (Varian bond-elute, 10 g) and washed with methanol. The methanolic fractions were concentrated in vacuo to afford the title compound (D5).

Aufarbeitung

  1. temperatureto cool
  2. washwashed with methanol
  3. concentrationThe methanolic fractions were concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7f326dce32854931a218dc9a33e9d305
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08207331B2

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