Hydrochloric Acid → HCID 18655126, compound

Participants

Reaction Steps

5.0 g of N2 -tert-butoxycarbonyl-N1 -[1-(5-nitro-2-benzofuranyl)ethyl]-L-valinamide was dissolved in 100 ml of tetrahydrofuran, and placed in a flow of hydrogen chloride gas for 1 hour at room temperature. The reaction mixture was then concentrated under reduced pressure, and the residual crude crystals obtained were washed with acetone to yield 3.6 g of the desired product (melting point: 211°-216° C.).

Provenance & Evidence