Hydrochloric Acid → HCID 18655126, compound

HRID 2226569Notes

Reaction equation

HRID 2226569 reaction equation
N#N.C(OC([NH:10][C@H:11]([C:15]([NH:17][CH:18]([C:20]1[O:21][C:22]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][C:23]=2[CH:24]=1)[CH3:19])=[O:16])[CH:12]([CH3:14])[CH3:13])=O)(C)(C)C.[ClH:32]>O1CCCC1>[ClH:32].[N+:29]([C:26]1[CH:27]=[CH:28][C:22]2[O:21][C:20]([CH:18]([NH:17][C:15](=[O:16])[C@H:11]([CH:12]([CH3:13])[CH3:14])[NH2:10])[CH3:19])=[CH:24][C:23]=2[CH:25]=1)([O-:31])=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86748151HCID 86748151, compound

Product 1

HCID 18655126HCID 18655126, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5.0 g of N2 -tert-butoxycarbonyl-N1 -[1-(5-nitro-2-benzofuranyl)ethyl]-L-valinamide was dissolved in 100 ml of tetrahydrofuran, and placed in a flow of hydrogen chloride gas for 1 hour at room temperature. The reaction mixture was then concentrated under reduced pressure, and the residual crude crystals obtained were washed with acetone to yield 3.6 g of the desired product (melting point: 211°-216° C.).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customthe residual crude crystals obtained
  3. washwere washed with acetone

Sources & evidence

ORD record
ord-c6bcdf6cf15a4741aee43eb3737cdfc2
Source dataset
uspto-grants-1994_09
Patent number
US05348976

Reaction notes

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