7-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepine → N-Methyl-6-(8-Iodo-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamide

HRID 222658Notes

Reaction equation

HRID 222658 reaction equation
[I:1][C:2]1[C:19]([O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([NH:29][CH3:30])=[O:28])=[CH:23][N:22]=2)=[CH:18][C:5]2[CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9][CH2:10][C:4]=2[CH:3]=1.C(OC1C=CC2CCNCCC=2C=1)C1C=CC=CC=1>>[CH3:30][NH:29][C:27]([C:24]1[CH:23]=[N:22][C:21]([O:20][C:19]2[C:2]([I:1])=[CH:3][C:4]3[CH2:10][CH2:9][NH:8][CH2:7][CH2:6][C:5]=3[CH:18]=2)=[CH:26][CH:25]=1)=[O:28]

Participants

3

Reactant 2

HCID 574376177-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 574402891,1-Dimethylethyl 7-Iodo-8-({5-[(methylamino)carbonyl]-2-pyridinyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Product 1

HCID 57440290N-Methyl-6-(8-Iodo-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamide

Procedure

Description 43 (D43) was prepared from 1,1-dimethylethyl 7-iodo-8-({5-[(methylamino)carbonyl]-2-pyridinyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (D42) using an analogous method to that described for Description 2 (D2); MS (ES+) m/e 424 [M+H]+.

Sources & evidence

ORD record
ord-4e8fed9896894bc79f67bcf4a26a8967
Source dataset
uspto-grants-2012_06
Patent number
US08207331B2

Reaction notes

Loading…