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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 222658Generated: October 25, 2026

7-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepine → N-Methyl-6-(8-Iodo-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamide

https://huagongshe.com/reaction/222658

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-(benzyloxy)-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 57437617—
Reactant1,1-Dimethylethyl 7-Iodo-8-({5-[(methylamino)carbonyl]-2-pyridinyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylateHCID 57440289—
ProductN-Methyl-6-(8-Iodo-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)-3-pyridinecarboxamideHCID 57440290—

Reaction Steps

Description 43 (D43) was prepared from 1,1-dimethylethyl 7-iodo-8-({5-[(methylamino)carbonyl]-2-pyridinyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (D42) using an analogous method to that described for Description 2 (D2); MS (ES+) m/e 424 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207331B2
Source datasetuspto-grants-2012_06
ORD IDord-4e8fed9896894bc79f67bcf4a26a8967
Source noteuspto-grants-2012_06