反应详情

1.2 g of 2-(4-fluorophenyl)-4-(3-hydroxyphenyl)-5-methoxypyrimidine, 5.5 g of potassium carbonate, and 5.5 g of 2-bromobutane were added to 200 ml of acetone, and the resulting mixture was heated under reflux for 2 days. The solvent was distilled away under reduced pressure. The residue was washed with water, and then purified by column chromatography on silica gel, thereby obtaining 1.0 g of 2-(4-fluorophenyl )-4-[3-sec-butoxyphenyl)-5-methoxypyrimidine (Compound 50).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 days
3. distillationThe solvent was distilled away under reduced pressure
4. washThe residue was washed with water
5. custompurified by column chromatography on silica gel