反应详情

2.5 g of m-trifluoromethyl-α-methanesulfonylacetophenone and 1.4 g of N,N-dimethylformamide dimethylacetal were dissolved in 40 ml of toluene, and the resulting mixture was heated under reflux for 2 hours. The solvent was distilled away under reduced pressure. The residue was treated with column chromatography on silica gel, thereby obtaining 3 g of 1-(3-trifluoromethylbenzoyl)-l-methanesulfonyl-2-(N,N-dimethylamino)ethene (Compound 205).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. distillationThe solvent was distilled away under reduced pressure
4. additionThe residue was treated with column chromatography on silica gel