Isobutyrophenone → 2-Methyl-2-(4-methylbenzene-1-sulfonyl)-1-phenylpropan-1-one

HRID 2226814Notes

Reaction equation

HRID 2226814 reaction equation
[C:1]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[C:12]1([CH3:35])[CH:17]=[CH:16][C:15]([S:18](OCC2C([N+]([O-])=O)=CC=CC=2[N+]([O-])=O)(=[O:20])=[O:19])=[CH:14][CH:13]=1.C1(S(C(S(C2CCCCC2)(=O)=O)=[N+]=[N-])(=O)=O)CCCCC1>>[CH3:3][C:2]([S:18]([C:15]1[CH:16]=[CH:17][C:12]([CH3:35])=[CH:13][CH:14]=1)(=[O:20])=[O:19])([CH3:4])[C:1]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5]

Participants

4

Reactant 3

HCID 69144IsobutyrophenoneHCID 11056751BIS(CYCLOHEXYLSULFONYL)DIAZOMETHANEHCID 11175590HCID 11175590, compound

Product 1

HCID 134452582-Methyl-2-(4-methylbenzene-1-sulfonyl)-1-phenylpropan-1-one

Procedure

Using isobutyrophenone, the reaction was carried out in the same manner as described in Synthesis Example 9, (2) and (3), the crude solid was recrystallized from methanol to afford 2-methyl-2-(p-toluenesulfonyl)propiophenone as a white needles.

Workup

  1. customthe crude solid was recrystallized from methanol

Sources & evidence

ORD record
ord-f4bdf8e6a09d4612b836e6276ec4a343
Source dataset
uspto-grants-1994_09
Patent number
US05350660

Reaction notes

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