Hydrochloric Acid → HCID 67805665, compound

Participants

Reaction Steps

A mixture of 2-acetylimino-3-(3-trifluoromethyl-4-fluorophenyl)-5-methylthiazoline (3.5 g) and hydrochloric acid (36%, 3.5 ml) in ethanol-water (35 ml) was refluxed for 3 hours. After cooling, the solvent was removed under reduced pressure, and the residue was isolated and washed with a little amount of iso-propanol and hexane to give 2.8 g of 3-(3-trifluoromethyl-4-fluorophenyl)-5-methyl-2-iminothiazoline hydrochloride (compound (i)).

Provenance & Evidence