Hydrochloric Acid → HCID 67805665, compound

HRID 2226828Notes

Reaction equation

HRID 2226828 reaction equation
C([N:4]=[C:5]1[N:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([C:17]([F:20])([F:19])[F:18])[CH:11]=2)[CH:8]=[C:7]([CH3:21])[S:6]1)(=O)C.[ClH:22]>C(O)C.O>[ClH:22].[F:19][C:17]([F:18])([F:20])[C:12]1[CH:11]=[C:10]([N:9]2[CH:8]=[C:7]([CH3:21])[S:6][C:5]2=[NH:4])[CH:15]=[CH:14][C:13]=1[F:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15219382HCID 15219382, compound

Product 1

HCID 67805665HCID 67805665, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of 2-acetylimino-3-(3-trifluoromethyl-4-fluorophenyl)-5-methylthiazoline (3.5 g) and hydrochloric acid (36%, 3.5 ml) in ethanol-water (35 ml) was refluxed for 3 hours. After cooling, the solvent was removed under reduced pressure, and the residue was isolated and washed with a little amount of iso-propanol and hexane to give 2.8 g of 3-(3-trifluoromethyl-4-fluorophenyl)-5-methyl-2-iminothiazoline hydrochloride (compound (i)).

Workup

  1. temperaturewas refluxed for 3 hours
  2. temperatureAfter cooling
  3. customthe solvent was removed under reduced pressure
  4. customthe residue was isolated
  5. washwashed with a little amount of iso-propanol and hexane

Sources & evidence

ORD record
ord-5d821a6765f14f89b574230fc096c1a4
Source dataset
uspto-grants-1994_09
Patent number
US05350736

Reaction notes

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