Formamide → 3H,4H-pyrido(3,4-d)pyrimidin-4-one

HRID 2226833Notes

Reaction equation

HRID 2226833 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=O.[CH:11]([NH2:13])=O>O>[N:1]1[C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[C:8](=[O:10])[NH:13][CH:11]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 4595313-Aminoisonicotinic acid

Product 1

HCID 1355671063H,4H-pyrido(3,4-d)pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4 g of 3-amino-pyridine-4-carboxylic acid in 15 mL of formamide was heated in an oil bath to 160°-180° C. After one hour the mixture was allowed to cool. Then, the mixture was slurried in 25 mL of water and filtered. The product was recrystallized from water. Yield 3.3 g. M.P. 317° C. (with sublimation).

Workup

  1. temperaturewas heated in an oil bath to 160°-180° C
  2. temperatureto cool
  3. filtrationfiltered
  4. customThe product was recrystallized from water

Sources & evidence

ORD record
ord-71caedaebab043d6a091fd5c9b9d0c0b
Source dataset
uspto-grants-1994_09
Patent number
US05350749

Reaction notes

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