HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 3H,4H-pyrido(3,4-d)pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 3-Aminoisonicotinic acid | HCID 459531 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3H,4H-pyrido(3,4-d)pyrimidin-4-one | HCID 135567106 | — |
Reaction Steps
A mixture of 4 g of 3-amino-pyridine-4-carboxylic acid in 15 mL of formamide was heated in an oil bath to 160°-180° C. After one hour the mixture was allowed to cool. Then, the mixture was slurried in 25 mL of water and filtered. The product was recrystallized from water. Yield 3.3 g. M.P. 317° C. (with sublimation).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05350749 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-71caedaebab043d6a091fd5c9b9d0c0b |
| Source note | uspto-grants-1994_09 |