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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2226872Generated: October 31, 2026

Formaldehyde → Methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate

https://huagongshe.com/reaction/2226872

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantMethyl 4-chloro-3-(dimethylamino)benzo[b]thiophene-2-carboxylateHCID 18963790—
ReactantMethyl 3-amino-5-(methylthio)-benzo[b]thiophene-2-carboxylateHCID 18963793—
ProductMethyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylateHCID 1896376271%

Reaction Steps

Prepared from methyl 3-amino-5-(methylthio)-benzo[b]thiophene-2-carboxylate by alkylation with formaldehyde as described in the preparation of methyl 4-chloro-3-(dimethylamino)benzo[b]thiophene-2-carboxylate. Yield 71% after recrystallization from ether-petroleum ether; mp=63°-66° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05350748
Source datasetuspto-grants-1994_09
ORD IDord-5f8c7cb9fcf74695ba5b0fdcad976373
Source noteuspto-grants-1994_09