反应详情

Prepared from methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate by reaction with lithium amide as described in Example 19. Purification of the crude product by flash chromatography (silica gel, elution with 30% ethyl acetate in hexane) gives 64% of product; mp=140°-142° C.

1. customPurification of the crude product
2. washby flash chromatography (silica gel, elution with 30% ethyl acetate in hexane)