HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium amide → 3-Dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium amide | HCID 24532 | — |
| Reactant | Methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate | HCID 18963762 | — |
| Product | 3-Dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxamide | HCID 18963776 | 64% |
Reaction Steps
Prepared from methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate by reaction with lithium amide as described in Example 19. Purification of the crude product by flash chromatography (silica gel, elution with 30% ethyl acetate in hexane) gives 64% of product; mp=140°-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05350748 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-7857070c950747879c9bcfc79a032e5e |
| Source note | uspto-grants-1994_09 |