Methylamine → HCID 18963791, compound

Participants

Reaction Steps

Monomethylamine gas is passed into a room temperature solution of 5-methoxy-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide-1-oxide (250 mg, 0.89 mmol) [Boschelli, et al., U.S. Pat. No. 5,208,253 (1993)] in acetonitrile. A precipitate forms almost immediately and stirring is continued for 30 minutes. The solid is collected and dried to provide 5-methoxy-3-(methylamino)benzo[b]thiophene-2-carboxamide-1-oxide in 86% yield; mp=244°-244.5° C. dec.

Provenance & Evidence