Methylamine → HCID 18963791, compound

HRID 2226874Notes

Reaction equation

HRID 2226874 reaction equation
[CH3:1][NH2:2].[CH3:3][O:4][C:5]1[CH:21]=[CH:20][C:8]2[S:9](=[O:19])[C:10]([C:16]([NH2:18])=[O:17])=[C:11](OC(C)C)[C:7]=2[CH:6]=1>C(#N)C>[CH3:3][O:4][C:5]1[CH:21]=[CH:20][C:8]2[S:9](=[O:19])[C:10]([C:16]([NH2:18])=[O:17])=[C:11]([NH:2][CH3:1])[C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 5481003148550-96-3

Product 1

HCID 18963791HCID 18963791, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Monomethylamine gas is passed into a room temperature solution of 5-methoxy-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide-1-oxide (250 mg, 0.89 mmol) [Boschelli, et al., U.S. Pat. No. 5,208,253 (1993)] in acetonitrile. A precipitate forms almost immediately and stirring is continued for 30 minutes. The solid is collected and dried to provide 5-methoxy-3-(methylamino)benzo[b]thiophene-2-carboxamide-1-oxide in 86% yield; mp=244°-244.5° C. dec.

Workup

  1. customis passed into a room temperature
  2. customThe solid is collected
  3. customdried

Sources & evidence

ORD record
ord-590c6faabef14893b90e5ea9f5b558bc
Source dataset
uspto-grants-1994_09
Patent number
US05350748

Reaction notes

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