Isopropylamine → HCID 18963764, compound

HRID 2226875Notes

Reaction equation

HRID 2226875 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH3:5][O:6][C:7]1[CH:23]=[CH:22][C:10]2[S:11](=[O:21])[C:12]([C:18]([NH2:20])=[O:19])=[C:13](OC(C)C)[C:9]=2[CH:8]=1>C(#N)C>[CH3:5][O:6][C:7]1[CH:23]=[CH:22][C:10]2[S:11](=[O:21])[C:12]([C:18]([NH2:20])=[O:19])=[C:13]([NH:4][CH:1]([CH3:3])[CH3:2])[C:9]=2[CH:8]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 5481003148550-96-3

Product 1

HCID 18963764HCID 18963764, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Isopropyl amine (379 μL, 4.45 mmol) is added to a room temperature solution of 5-methoxy-(3-(1-methylethoxy))benzo[b]thiophene-2-carboxamide-1-oxide (250 mg, 0.89 mmol) in 25 mL of acetonitrile. Stirring is continued for 16 hours. The reaction mixture is concentrated and recrystallized from acetonitrile to provide 5-methoxy-3-[(1-methylethyl)amino]benzo[b]thiophene-2-carboxamide-1-oxide in 64% yield; mp=193.5°-194.5° C.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-0f1def0e71be4f51857bcd0fce036669
Source dataset
uspto-grants-1994_09
Patent number
US05350748

Reaction notes

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