HCID 15233845, compound → HCID 18963999, compound

HRID 2226933Notes

Reaction equation

HRID 2226933 reaction equation
C1(C[O:8][C:9]2[CH:17]=[CH:16][C:15]3[N:14]([CH3:18])[C:13]4[CH2:19][CH:20]([CH2:22][N:23]([CH3:25])[CH3:24])[CH2:21][C:12]=4[C:11]=3[CH:10]=2)C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:18][N:14]1[C:15]2[CH:16]=[CH:17][C:9]([OH:8])=[CH:10][C:11]=2[C:12]2[CH2:21][CH:20]([CH2:22][N:23]([CH3:25])[CH3:24])[CH2:19][C:13]1=2

Participants

5

Reactant 2

HCID 15233845HCID 15233845, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18963999HCID 18963999, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

In a 500 ml Parr hydrogenation bottle was suspended 0.5 g of 10% Pd/C in 50 ml of ethyl alcohol. To this was added a solution of 1,2,3,4-tetrahydro-7-phenylmethoxy-N,N,4-trimethylcyclopent[b]indole-2-methanamine (2.3 g, 0.007 mole) in 200 ml of ethyl alcohol. After shaking at 50° C. under 50 psi hydrogen for two hours, the mixture was cooled and filtered, and the filtrate concentrated to a tan solid, 1.5 g, m.p. 110° C.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated to a tan solid, 1.5 g, m.p. 110° C.

Sources & evidence

ORD record
ord-080d97b790fc4f2daac6c5668585a883
Source dataset
uspto-grants-1994_09
Patent number
US05350762

Reaction notes

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