p-Anisoyl chloride → HCID 1744311, compound

HRID 2226959Notes

Reaction equation

HRID 2226959 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.C(N(CC)CC)C.[C:19]1([CH2:25][CH2:26][CH2:27][NH2:28])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)Cl>[C:19]1([CH2:25][CH2:26][CH2:27][NH:28][C:7](=[O:8])[C:6]2[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 162593-Phenylpropylamine

Product 1

HCID 1744311HCID 1744311, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of p-methoxybenzoyl chloride (37.8 g, .222 mol) in CH2Cl2 (200 ml) at 0°, is added triethylamine (22.5 g, .222 mol) followed by the slow addition of 3-phenylpropylamine (20 g,.148 mol) dissolved in CH2Cl2 (100 ml). The reaction is allowed to warm to room temperature over several hours. The solvent is removed in vacuo, and the residue is dissolved in EtOAc (500 ml) and 2N HCl (500 ml). The EtOAc is separated, washed with 2NHCl (350 ml), H2O (350 ml), saturated NaHCO3 solution (350 ml), and saturated NaCl solution (350 ml); dried over MgSO4 ; and evaporated. The resulting light brown solid is purified by chromatography (SiO2 ;1:9 EtOAc/hexanes, 1:4 EtOAc/hexanes) yielding N-(3-phenylpropyl)-4-methoxybenzamide as creamy solid.

Workup

  1. customThe solvent is removed in vacuo
  2. dissolutionthe residue is dissolved in EtOAc (500 ml)
  3. customThe EtOAc is separated
  4. washwashed with 2NHCl (350 ml), H2O (350 ml), saturated NaHCO3 solution (350 ml), and saturated NaCl solution (350 ml)
  5. dry with materialdried over MgSO4
  6. customand evaporated
  7. customThe resulting light brown solid is purified by chromatography (SiO2 ;1:9 EtOAc/hexanes, 1:4 EtOAc/hexanes)

Sources & evidence

ORD record
ord-c7aed435411343b7b961779eed55e240
Source dataset
uspto-grants-1994_09
Patent number
US05350761

Reaction notes

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