HCID 12571954, compound → HCID 12455099, compound

HRID 2226976Notes

Reaction equation

HRID 2226976 reaction equation
C([NH:4][C:5]1[CH:9]=[CH:8][S:7][C:6]=1[S:10][C:11](=O)[CH3:12])(=O)C>C1(C)C=CC=CC=1>[CH3:12][C:11]1[S:10][C:6]2[S:7][CH:8]=[CH:9][C:5]=2[N:4]=1

Participants

3

Reactant 1

HCID 12571954HCID 12571954, compound

Product 1

HCID 12455099HCID 12455099, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
205 °C

Procedure

A solution of 660 mg (3.1 mmol) of N-acetyl-2-(acetylthio)-3-thiophenamine in 8 ml of toluene was degased in a pyrex tube under high vacuum. The tube was subsequently sealed under high vacuum and heated at 205° C. for 5 hr. Chromatographic separation on silica gel using hexane/EtOAc=5:1 gave 440 mg (80%) of product. 1H NMR (CDCl3) 7.40(s, 2H), 2.82(s, 3H)

Workup

  1. customThe tube was subsequently sealed under high vacuum
  2. customChromatographic separation on silica gel

Sources & evidence

ORD record
ord-75c9d5d1bf1e4ddbb06792a6edbf27f2
Source dataset
uspto-grants-1994_09
Patent number
US05350760

Reaction notes

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