Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 2227020Notes

Reaction equation

HRID 2227020 reaction equation
[CH:1](=O)[C:2]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:4]([O:5][CH3:6])[CH:3]=1.[CH:13]([OH:15])=[O:14].[CH2:16](N(CC)CC)C>>[CH3:6][O:5][C:4]1[CH:3]=[C:2]([CH2:1][CH2:16][C:13]([OH:15])=[O:14])[CH:11]=[CH:10][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 8419VeratraldehydeHCID 8471Triethylamine

Product 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Procedure

4.60 g (0.025 mol) of 2,2-pentamethylene-1,3-dioxane-4,6-dione (m.p.: 94° C.) and 4.15 g (0.025 mol) of veratraldehyde were added to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1. The reaction was carried out according to Example 1.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-94c5c2e27c3b4ab9a2af3eee2a487ab3
Source dataset
uspto-grants-1994_09
Patent number
US05350872

Reaction notes

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