Methyl 6-chloropyridine-3-carboxylate → 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarboxylic acid methyl ester
Reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[CH:22][C:21]([C:24]([O:26][CH3:27])=[O:25])=[CH:20][CH:19]=1.COC(C1C=NC(OC2C=CC3CCN(C4CCC4)CCC=3C=2)=CN=1)=O>>[CH3:27][O:26][C:24]([C:21]1[CH:22]=[N:23][C:18]([O:16][C:13]2[CH:14]=[CH:15][C:8]3[CH2:7][CH2:6][N:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)[CH2:11][CH2:10][C:9]=3[CH:12]=2)=[CH:19][CH:20]=1)=[O:25]Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared from 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and methyl 6-chloro-3-pyridine carboxylate in an analogous manner to that described for E122; MS (ES+) m/e 353 [M+H]+.
Sources & evidence
- ORD record
- ord-e0122039257b46cb9adeb5aed4af8f76
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08207331B2
Reaction notes
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