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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 222705Generated: October 30, 2026

Methyl 6-chloropyridine-3-carboxylate → 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarboxylic acid methyl ester

https://huagongshe.com/reaction/222705

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-chloropyridine-3-carboxylateHCID 254249—
Reactant3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OLHCID 10082081—
Reactant5-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-pyrazine-2-carboxylic acid methyl esterHCID 10473278—
Product6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarboxylic acid methyl esterHCID 10020904—

Reaction Steps

The title compound was prepared from 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and methyl 6-chloro-3-pyridine carboxylate in an analogous manner to that described for E122; MS (ES+) m/e 353 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207331B2
Source datasetuspto-grants-2012_06
ORD IDord-e0122039257b46cb9adeb5aed4af8f76
Source noteuspto-grants-2012_06