Triphenylphosphine → [3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane 3C (4.2 g) in anhydrous dimethylformamide (11.3 mL) is added triphenylphosphine (6.12 g). The reaction mixture is stirred under nitrogen at 100° C. overnight. The reaction mixture is then cooled to room temperature. The white precipitate is filtered and washed with ethyl acetate, then dried under vacuum.

Provenance & Evidence